doi: 10.5152/jtgga.2012.08
Polikistik over sendromlu hastalarda total ve lipid bağlı sialik asit seviyeleri
Ali Özcan1, Aykan Yücel1, Volkan Noyan1, Nevin Sağsöz1, Osman Çağlayan2
1Kırıkkale Üniversitesi, Tıp Fakültesi, Kadin Hastaliklari Ve Doğum Ad, Kırıkkale, Türkiye
2Kırıkkale Üniversitesi, Tıp Fakültesi, Biokimya Ad, Kırıkkale, Türkiye
Amaç: Polikistik over sendromlu hastalarda (PKOS) serum total ve lipid bağlı sialik asit (TSA&LBSA) düzeylerinin değerlendirilmesi.
Gereç ve Yöntemler: Çalışmaya kırk PKOS'lu hasta ve 35 sağlıklı kontrol dahil edildi. Her olguda serumda TSA, LBSA, folikül stimülan hormon, luteinizan hormon, östradiol, tiroid stimülan hormon, prolaktin, dehidroepiandrosteron sülfat, androstenedion, serbest testosteron, total testosteron, 17-OH progesteron, seks hormon bağlayıcı globulin, kortizol, total kolesterol, trigliserid, yüksek densiteli lipoprotein ve düşük densiteli lipoprotein ölçüldü. Açlık insülin seviyesi, açlık glükozu/insülin oranı ve 2 saatlik 75-g glükoz tolerans testi ile insülin rezistansı değerlendirildi.
Bulgular: Serum TSA seviyeleri açısından gruplar arasında anlamlı fark yoktu. Kontrol grubuna göre karşılaştırıldığında PKOS'lu hastalarda serum LBSA seviyeleri yüksekti. PKOS grubunda TSA, androstenedione ve HOMA-IR ile korele bulundu. PKOS'lu hastalarda LBSA ile dehidroepiandrosteron sulfat arasında pozitif korelasyon bulundu. BMI'ya göre düzeltme sonrası, kalan tek anlamlı korelasyon LBSA ile folikül stimülan hormon arasında idi.
Sonuç: Kardiyovasküler hastalıklarda ve diabette arttığı bilinen LBSA'nın serum seviyeleri PKOS'da yükselir. Anahtar Kelimeler: Polikistik over sendromu, total sialik asit, lipid bağlı sialik asit, risk
Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome
Ali Özcan1, Aykan Yücel1, Volkan Noyan1, Nevin Sağsöz1, Osman Çağlayan2
1Department Of Gynecology And Obstetrics, Faculty Of Medicine, Kırıkkale University, Kırıkkale, Turkey
2Department Of Biochemistry And Clinical Biochemistry, Faculty Of Medicine, Kırıkkale University, Kırıkkale, Turkey
Objective: To evaluate serum total and lipid bound sialic acid (TSA&LBSA) levels in patients with polycystic ovary syndrome (PCOS).
Material and Methods: Forty women with PCOS and 35 healthy controls were enrolled in the study. Serum TSA, LBSA, follicle stimulating hormone, lutenizing hormone, estradiol, thyroid stimulating hormone, prolactin, dehydroepiandrosterone sulphate, androstenedione, free testosterone, total testosterone, 17-OH progesterone, sex hormone binding globulin, cortisol, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75-g glucose tolerance test for 2 hours.
Results: Serum TSA levels were not significantly different between the groups. Serum LBSA levels were higher in patients with PCOS compared to the control group. TSA was correlated with androstenedione and HOMA-IR in the PCOS group. Positive correlations were found between LBSA and dehydroepiandrosterone sulphate in patients with PCOS. After correction for BMI, the only existing significant correlation was between LBSA and follicle stimulating hormone.
Conclusion: Serum LBSA levels, which has previously been found to be higher in cardiovascular diseases and diabetes mellitus, are elevated in PCOS. Key words: Polycystic ovary syndrome, total sialic acid, lipid bound sialic acid, risk
Ali Özcan, Aykan Yücel, Volkan Noyan, Nevin Sağsöz, Osman Çağlayan. Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome. J Turkish German Gynecol Assoc. 2012; 13(2): 79-84 Corresponding Author: Aykan Yücel, Türkiye: aykanyucel@gmail.com |
