Objective:

To investigate the correlation between maternal leptin levels and 100 gram oral glucose test (OGTT) results as well as the correlation between leptin levels and the development of gestational diabetes mellitus (GDM) and glucose intolerance during pregnancy.

Material and Method:

104 subjects with gestational weeks ranging from 24 to 32 weeks that have increased 50 gr OGTT values (> 140) were included in this study. After the screening test, 100 gr OGTT was administered to the subjects.Sixty cases were selected out of these subjects; twenty patients with one abnormal test result were identified as “glucose intolerant” group (Group 1), 20 patients with two abnormal test values were diagnosed with GDM (Group 2). 20 patients with normal test results constituted the control group. The serum leptin levels of the groups were measured with enzyme linked immunosorbent assay (ELISA).

Results:

The serum leptin level was 8.4±5.1 ng/ml for group 1, 9.1±5.3 ng/ml for group 2, 6.3±4.6 ng/ml for the control group. Although serum leptin levels for group 1 and 2 was observed to be higher than the control group, the result was not statistically significant (p>0.05). This result did not change after adjusting for body mass index (BMI).

Conclusion:

There is no statistically significant difference between leptin levels among three groups.

Keywords: Gestational Diabetes Mellitus, Oral Glucose Tolerance Test, Leptin